Ocular fundus pathology and chronic kidney disease in a Chinese population.

Abstract

ABSTRACT:

BACKGROUND:

Previous study indicated a high prevalence of ocular fundus pathology among patients with chronic kidney disease (CKD), while the relationship between them has never been explored in a Chinese Population.

METHODS:

This cross-sectional study included 9 670 participants enrolled in a medical screening program. Ocular fundus examination was performed by ophthalmologists using ophthalmoscopes. The presence of eGFR less than 60 mL/min/1.73 m2 and/or proteinuria was defined as CKD.

RESULTS:

Compared to participants without CKD, participants with CKD had higher prevalence of retinopathy (28.5% vs. 16.3%, P<0.001), glaucoma suspect (3.1% vs. 1.8%, P=0.004), age-related macular degeneration (1.7% vs. 0.9%, P=0.01) and overall eye pathology (32.0% vs. 19.4%, P<0.001). After adjusting for potential confounders, the odds ratio of proteinuria for overall eye pathology and retinopathy was 1.29 (95% confidence interval [CI] 1.07-1.55) and 1.37 (95% CI 1.12-1.67), respectively. The results were robust after excluding participants with hypertension or with diabetes.

CONCLUSIONS:

Ocular fundus pathology is common among Chinese patients with CKD. Regular eye exam among persons with proteinuria is warranted.

Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22093232&dopt=Abstract

derrick mason derrick mason lamichael james lamichael james epstein harrisburg pa chynna phillips